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J Clin Exp Neuropsychol. 2010 Aug;32(7):767-74. doi: 10.1080/13803390903521000. Epub 2010 Mar 1.

Persistent symptoms in mild to moderate traumatic brain injury associated with executive dysfunction.

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Department of Neurology, Tampere University Hospital, Tampere, Finland.


In order to improve detection of subtle cognitive dysfunction and to shed light on the etiology of persistent symptoms after mild-to-moderate traumatic brain injury (TBI), we employed an experimental executive reaction time (RT) test, standardized neuropsychological tests, and diffusion tensor imaging (DTI). The Executive RT-Test, an Executive Composite Score from standardized neuropsychological tests, and DTI-indices in the midbrain differentiated between patients with persistent symptoms from those fully recovered after mild-to-moderate TBI. We suggest that persistent symptoms in mild-to-moderate TBI may reflect disrupted fronto-striatal network involved in executive functioning, and the Executive RT-Test provides an objective and novel method to detect it.

[Indexed for MEDLINE]

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