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AAPS J. 2010 Jun;12(2):223-32. doi: 10.1208/s12248-010-9181-5. Epub 2010 Mar 3.

Pancreatic cancer: pathobiology, treatment options, and drug delivery.

Author information

1
College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment options for pancreatic cancer. Moreover, the review discusses the opportunities of developing novel therapies for pancreatic cancer provided by the progress in understanding the genetic mutations, tumor microenvironment, cancer stem cells, and drug delivery.

PMID:
20198462
PMCID:
PMC2844509
DOI:
10.1208/s12248-010-9181-5
[Indexed for MEDLINE]
Free PMC Article

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