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Korean J Lab Med. 2010 Feb;30(1):28-33. doi: 10.3343/kjlm.2010.30.1.28.

[Antimicrobial susceptibility patterns of Legionella isolates in the environment and in patients].

[Article in Korean]

Author information

1
Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea.

Erratum in

  • Korean J Lab Med. 2010 Apr;30(2):201.

Abstract

BACKGROUND:

Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics.

METHODS:

We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth.

RESULTS:

The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows: 0.004-0.062 microg/mL (azithromycin), 0.002-0.5 microg/mL (ciprofloxacin), 0.004-0.5 microg/mL (clarithromycin), 0.12-4 microg/mL (clindamycin), 0.002-0.12 microg/mL (gatifloxacin), and 0.008-1 microg/mL (gemifloxacin).

CONCLUSIONS:

Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.

PMID:
20197719
DOI:
10.3343/kjlm.2010.30.1.28
[Indexed for MEDLINE]
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