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Vaccine. 2010 Apr 19;28(18):3080-5. doi: 10.1016/j.vaccine.2010.02.081. Epub 2010 Mar 1.

The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant.

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Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada.


3', 5'-Cyclic diguanylic acid (c-di-GMP) is a bacterial intracellular signaling molecule that plays a crucial role in the regulation of bacterial motility, adhesion, cell-to-cell communication, exopolysaccharide synthesis, biofilm formation and virulence. The recent finding that c-di-GMP can act as a danger signal on eukaryotic cells has prompted the study of the immunostimulatory and immunomodulatory properties of c-di-GMP in an effort to determine whether c-di-GMP might be further developed as a potential vaccine adjuvant. In this review, we discussed the recent in vitro and in vivo studies of the immunostimulatory properties of c-di-GMP and the progress that has been made in the preclinical development of c-di-GMP as a potential vaccine adjuvant for systemic and mucosal vaccination.

[Indexed for MEDLINE]

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