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Cell Metab. 2010 Mar 3;11(3):179-81. doi: 10.1016/j.cmet.2010.02.004.

New uses for old drugs: neonatal diabetes and sulphonylureas.

Author information

1
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, UK. frances.ashcroft@dpag.ox.ac.uk

Abstract

The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy.

PMID:
20197050
DOI:
10.1016/j.cmet.2010.02.004
[Indexed for MEDLINE]
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