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Stat Appl Genet Mol Biol. 2010;9:Article 12. doi: 10.2202/1544-6115.1525. Epub 2010 Jan 26.

An alternative model of type A dependence in a gene set of correlated genes.

Author information

1
Seoul National University. johanlim@snu.ac.kr

Abstract

Klebanov et al. (2006) proposed a new type of stochastic dependence, Type A dependence, between gene expression levels. They estimated the abundance of Type A pairs by testing the correlation coefficients of gene pairs. We propose a new model, hidden regulator dependence, as an alternative to Type A dependence. We show that the correlation based procedure proposed by Klebanov et al. (2006) fails to differentiate hidden regulator dependence from Type A dependence, although their probabilistic structures are quite different.

PMID:
20196747
DOI:
10.2202/1544-6115.1525
[Indexed for MEDLINE]
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