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Org Lett. 2010 Apr 2;12(7):1604-7. doi: 10.1021/ol100337m.

Highly efficient, facile, room temperature intermolecular [5 + 2] cycloadditions catalyzed by cationic rhodium(I): one step to cycloheptenes and their libraries.

Author information

1
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu

Abstract

A cationic rhodium(I) complex--[(C(10)H(8))Rh(cod)](+) SbF(6)(-)--catalyzes the remarkably efficient intermolecular [5 + 2] cycloaddition of vinylcyclopropanes (VCPs) and various alkynes, providing cycloheptene cycloadducts in excellent yields in minutes at room temperature. The efficacy and selectivity of this catalyst are also shown in a novel diversification strategy, affording a cycloadduct library in one step from nine commercially available components.

PMID:
20196579
DOI:
10.1021/ol100337m
[Indexed for MEDLINE]

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