Selective MMP13 inhibitors

Med Res Rev. 2011 Nov;31(6):863-94. doi: 10.1002/med.20204. Epub 2010 Mar 1.

Abstract

Pharmacology of MMP13 and MMP13 selective inhibitors is reviewed.

Publication types

  • Review

MeSH terms

  • Allosteric Site
  • Animals
  • Cartilage / metabolism
  • Collagen / chemistry
  • Drug Design
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Inflammation
  • Kinetics
  • Matrix Metalloproteinase Inhibitors*
  • Mice
  • Mice, Knockout
  • Osteoarthritis / drug therapy*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Rats

Substances

  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Collagen