Format

Send to

Choose Destination
Mech Ageing Dev. 2010 Apr;131(4):225-35. doi: 10.1016/j.mad.2010.02.003. Epub 2010 Mar 1.

Is coenzyme Q a key factor in aging?

Author information

1
Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide, CIBERER-Instituto de Salud Carlos III, Carretera de Utrera, Km 1, 41013 Sevilla, Spain.

Abstract

Coenzyme Q (Q) is a key component for bioenergetics and antioxidant protection in the cell. During the last years, research on diseases linked to Q-deficiency has highlighted the essential role of this lipid in cell physiology. Q levels are also affected during aging and neurodegenerative diseases. Therefore, therapies based on dietary supplementation with Q must be considered in cases of Q deficiency such as in aging. However, the low bioavailability of dietary Q for muscle and brain obligates to design new mechanisms to increase the uptake of this compound in these tissues. In the present review we show a complete picture of the different functions of Q in cell physiology and their relationship to age and age-related diseases. Furthermore, we describe the problems associated with dietary Q uptake and the mechanisms currently used to increase its uptake or even its biosynthesis in cells. Strategies to increase Q levels in tissues are indicated.

PMID:
20193705
DOI:
10.1016/j.mad.2010.02.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center