Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2010 Apr;13(4):501-6. doi: 10.1038/nn.2498. Epub 2010 Feb 28.

Resistance to forgetting associated with hippocampus-mediated reactivation during new learning.

Author information

1
Department of Psychology, Stanford University, Stanford, California, USA. brice.kuhl@yale.edu

Abstract

One of the reasons why we forget past experiences is because we acquire new memories in the interim. Although the hippocampus is thought to be important for acquiring and retaining memories, there is little evidence linking neural operations during new learning to the forgetting (or remembering) of earlier events. We found that, during the encoding of new memories, responses in the human hippocampus are predictive of the retention of memories for previously experienced, overlapping events. This brain-behavior relationship is evident in neural responses to individual events and in differences across individuals. We found that the hippocampus accomplishes this function by reactivating older memories as new memories are formed; in this case, reactivating neural responses that represented monetary rewards associated with older memories. These data reveal a fundamental mechanism by which the hippocampus tempers the forgetting of older memories as newer memories are acquired.

Comment in

PMID:
20190745
PMCID:
PMC2847013
DOI:
10.1038/nn.2498
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center