Format

Send to

Choose Destination
Clin Orthop Relat Res. 1991 May;(266):285-94.

Foreign-body-associated experimental osteomyelitis induced with Bacteroides fragilis and Staphylococcus epidermidis in rabbits.

Author information

1
Department of Microbiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.

Abstract

Bacteroides fragilis and Staphylococcus epidermidis, alone and in combination, were used to induce foreign-body-associated osteomyelitis in a rabbit model. In this model, a catheter, used as a foreign body, was implanted into the medullary cavity of the tibia. Only two of five animals infected with S. epidermidis alone developed culture-positive osteomyelitis, whereas all three animals infected with B. fragilis alone developed osteomyelitis. All six animals infected with both microorganisms developed culture-positive osteomyelitis. Roentgenographic and histologic evaluations confirmed the diagnosis of osteomyelitis. Transmission and scanning electron microscopy showed that when the two microorganisms are involved in a mixed infection, S. epidermidis predominates on the foreign body and B. fragilis predominates in the infected bone and marrow.

PMID:
2019061
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center