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J Surg Res. 2011 Nov;171(1):151-8. doi: 10.1016/j.jss.2009.11.721. Epub 2010 Feb 6.

A comprehensive analysis of parotid and salivary gland cancer: worse outcomes for male gender.

Author information

1
DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

Abstract

BACKGROUND:

To determine the effects of patient demographics, socioeconomic status (SES) and clinical variables on outcomes for patients with salivary and parotid gland tumors.

METHODS:

Florida cancer registry and inpatient hospital data were queried for cancer of the salivary glands diagnosed between 1998-2002.

RESULTS:

A total of 1573 patients were identified. Women were diagnosed at a younger age (median age (years): women 60.8 versus men 64.3, P=0.003). Men were more often diagnosed with high grade tumors (65.1% versus 41.9% for women, P<0.001) and advanced disease stage (>stage III: 60.2 versus 49.4%, P<0.001), but underwent surgical extirpation and received radiation at equal rates compared with women. Overall 5-year survival rates was superior in women (67.4% versus 55.6%, P=0.001). By multivariate analysis, adjusted for patient comorbidities, age over 65 (HR 3.43 P=0.008), advanced disease stage (HR 8.05 P<0.001), and high tumor grade (HR 2.33, P<0.001) were independent predictors of worse prognosis. Improved outcomes were observed for female gender (HR 0.68, P=0.011). Tumors located in the parotid gland (HR 0.631 P=0.003) and receiving both surgical extirpation and radiation were predictors of improved survival.

CONCLUSION:

Salivary gland tumors carry a worse prognosis than tumors of the parotid. Male patients have worse outcomes.

PMID:
20189602
DOI:
10.1016/j.jss.2009.11.721
[Indexed for MEDLINE]

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