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Bioorg Med Chem Lett. 2010 Apr 1;20(7):2224-8. doi: 10.1016/j.bmcl.2010.02.018. Epub 2010 Feb 8.

Identification of amide bioisosteres of triazole oxytocin antagonists.

Author information

1
Discovery Chemistry, Pfizer Global Research and Development, Sandwich, United Kingdom. Alan.D.Brown@pfizer.com

Abstract

A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. A range of potent analogues were identified, although SAR for potency and selectivity over the related V(1A) and V(2) receptors was found to be somewhat divergent from that observed for the corresponding triazole series. The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left hand side (biaryl replacement) substituents which gave good levels of oxytocin antagonism.

PMID:
20189387
DOI:
10.1016/j.bmcl.2010.02.018
[Indexed for MEDLINE]

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