Format

Send to

Choose Destination
Fertil Steril. 2010 Nov;94(6):2096-101. doi: 10.1016/j.fertnstert.2009.12.079. Epub 2010 Mar 1.

The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy.

Author information

1
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway.

DESIGN:

Observational prospective study.

SETTING:

A tertiary referral fertility clinic at the Erasmus University Medical Centre, Rotterdam, The Netherlands.

PATIENT(S):

One hundred sixty-one couples undergoing IVF/ICSI treatment.

INTERVENTION(S):

No interventions other than the Dutch governmental recommendation of folic acid.

MAIN OUTCOME MEASURE(S):

Dietary patterns, blood and follicular fluid concentrations of folate, vitamin B12, vitamin B6, homocysteine, and fertilization rate, embryo quality, and pregnancy.

RESULT(S):

In women, two dietary patterns were identified. The "health conscious-low processed" dietary pattern (variation explained 12.1%) was characterized by high intakes of fruits, vegetables, fish, and whole grains and low intakes of snacks, meats, and mayonnaise, and positively correlated with red blood cell folate (β=0.07). The "Mediterranean" dietary pattern (variation explained 9.1%), that is, high intakes of vegetable oils, vegetables, fish, and legumes and low intakes of snacks, was positively correlated with red blood cell folate (β=0.13), and vitamin B6 in blood (β=0.09) and follicular fluid (β=0.18). High adherence by the couple to the "Mediterranean" diet increased the probability of pregnancy, odds ratio 1.4 (95% confidence interval 1.0-1.9).

CONCLUSION(S):

A preconception "Mediterranean" diet by couples undergoing IVF/ICSI treatment contributes to the success of achieving pregnancy.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center