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Neuron. 2010 Feb 25;65(4):503-15. doi: 10.1016/j.neuron.2010.01.035.

The immune protein CD3zeta is required for normal development of neural circuits in the retina.

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1
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Emerging evidence suggests that immune proteins regulate activity-dependent synapse formation in the central nervous system (CNS). Mice with mutations in class I major histocompatibility complex (MHCI) genes have incomplete eye-specific segregation of retinal ganglion cell (RGC) axon projections to the CNS. This effect has been attributed to causes that are nonretinal in origin. We show that a key component of MHCI receptor, CD3zeta, is expressed in RGCs. CD3zeta-deficient mice have reduced RGC dendritic motility, an increase in RGC dendritic density, and a selective defect of glutamate-receptor-mediated synaptic activity in the retina. Disrupted RGC synaptic activity and dendritic motility is associated with a failure of eye-specific segregation of RGC axon projections to the CNS. These results provide direct evidence of an unrecognized requirement for immune proteins in the developmental regulation of RGC synaptic wiring and indicate a possible retinal origin for the disruption of eye-specific segregation found in immune-deficient mice.

PMID:
20188655
PMCID:
PMC3037728
DOI:
10.1016/j.neuron.2010.01.035
[Indexed for MEDLINE]
Free PMC Article
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