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Mov Disord. 2010;25 Suppl 1:S32-9. doi: 10.1002/mds.22798.

The role of parkin in familial and sporadic Parkinson's disease.

Author information

1
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. tdawson@jhmi.edu

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.

PMID:
20187240
PMCID:
PMC4115293
DOI:
10.1002/mds.22798
[Indexed for MEDLINE]
Free PMC Article

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