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Magn Reson Med. 2010 Mar;63(3):811-6. doi: 10.1002/mrm.22171.

The influence of temporal resolution in determining pharmacokinetic parameters from DCE-MRI data.

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Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.


We investigated the influence of the temporal resolution of dynamic contrast-enhanced MRI data on pharmacokinetic parameter estimation. Dynamic Gd-DTPA (Gadolinium-diethylene triamine pentaacetic acid) enhanced MRI data of implanted prostate tumors on rat hind limb were acquired at 4.7 T, with a temporal resolution of approximately 5 sec. The data were subsequently downsampled to temporal resolutions in the range of 15 sec to 85 sec, using a strategy that involves a recombination of k-space data. A basic two-compartment model was fit to the contrast agent uptake curves. The results demonstrated that as temporal resolution decreases, the volume transfer constant (K(trans)) is progressively underestimated (approximately 4% to approximately 25%), and the fractional extravascular extracellular space (v(e)) is progressively overestimated (approximately 1% to approximately 10%). The proposed downsampling strategy simulates the influence of temporal resolution more realistically than simply downsampling by removing samples.

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