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Dev Dyn. 2010 May;239(5):1460-4. doi: 10.1002/dvdy.22253.

Caenorhabditis elegans: a new model organism for studies of axon regeneration.

Author information

1
Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, California 92093, USA.

Abstract

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes.

PMID:
20186917
PMCID:
PMC3069807
DOI:
10.1002/dvdy.22253
[Indexed for MEDLINE]
Free PMC Article

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