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Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1282-8. doi: 10.1167/iovs.09-4366.

Deactivation mechanisms of rod phototransduction: the Cogan lecture.

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  • 1Department of Ophthalmology and Vision Science and Center for Neuroscience, University of California, Davis, California, USA

Abstract

The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

PMID:
20185839
PMCID:
PMC2845640
DOI:
10.1167/iovs.09-4366
[PubMed - indexed for MEDLINE]
Free PMC Article
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