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Nat Prod Commun. 2010 Jan;5(1):103-6.

Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.

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Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Rd, Caugiay, Hanoi, Vietnam.


Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.

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