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J Asian Nat Prod Res. 2009 Jul;11(7):604-12. doi: 10.1080/10286020902843152.

Ginsenoside Rg1 inhibits beta-secretase activity in vitro and protects against Abeta-induced cytotoxicity in PC12 cells.

Author information

1
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract

Ginsenoside Rg1 (1) is a major active component of Panax notoginseng, a Chinese herb widely used in traditional Chinese medicine to improve learning and memory function. Increasing evidence suggests that beta-amyloid peptide (Abeta) plays a central role in the pathophysiology of Alzheimer's disease (AD). To elucidate the mechanism of 1 on improving the ability of learning and memory, we investigated whether 1 could affect Abeta generation or protect Abeta-induced neurotoxicity. The results showed that 1 could inhibit beta-secretase activity in vitro and also protect the PC12 cells against injuries caused by exposure of PC12 cells to 50 microM Abeta(25-35) for 48 h. The cell death, LDH release, NO release, ROS production, lipid peroxidation, intracellular calcium elevation, and apoptosis are associated events induced by Abeta that can be rescued by 1 in PC12 cells. In conclusion, 1 may be a promising agent for AD, and the mechanism is related to beta-secretase inhibition and protection against Abeta-induced cytotoxicity.

PMID:
20183297
DOI:
10.1080/10286020902843152
[Indexed for MEDLINE]

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