Abstract
Three new constituents were obtained along with 10 known compounds from the seeds of Brucea javanica. The structures of these compounds were determined based on spectral and chemical evidence. These new compounds included a monoterpenoid glycoside and two sesquiterpenes. Bioactivity screening of these constituents showed that compounds 1, 3, 8, 9, and 13 with obvious activities in inhibiting multiplication of the Tobacco mosaic virus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Brucea / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Galactosides / chemistry
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Galactosides / isolation & purification*
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Galactosides / pharmacology
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Molecular Structure
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Seeds / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tobacco Mosaic Virus / drug effects*
Substances
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Antineoplastic Agents, Phytogenic
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Antiviral Agents
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Drugs, Chinese Herbal
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Galactosides
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Sesquiterpenes
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Terpenes
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brucojavan 1
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brucojavan 2