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Mediators Inflamm. 2010;2010:453892. doi: 10.1155/2010/453892. Epub 2010 Feb 16.

Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.

Author information

1
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. kaneto@endmet.med.osaka-u.ac.jp

Abstract

Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic beta-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate beta-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.

PMID:
20182627
PMCID:
PMC2825658
DOI:
10.1155/2010/453892
[Indexed for MEDLINE]
Free PMC Article

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