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Nat Rev Immunol. 2010 Mar;10(3):201-9. doi: 10.1038/nri2726.

Awakening dormant haematopoietic stem cells.

Author information

1
Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany. a.trumpp@dkfz.de

Abstract

Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells. During homeostasis, signals from this environment keep some HSCs dormant, which preserves long-term self-renewal potential, while other HSCs actively self renew to maintain haematopoiesis. In response to haematopoietic stress, dormant HSCs become activated and rapidly replenish the haematopoietic system. Interestingly, three factors - granulocyte colony-stimulating factor, interferon-alpha and arsenic trioxide - have been shown to efficiently activate dormant stem cells and thereby could break their resistance to anti-proliferative chemotherapeutics. Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies.

PMID:
20182459
DOI:
10.1038/nri2726
[Indexed for MEDLINE]

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