Format

Send to

Choose Destination
Nat Rev Immunol. 2010 Mar;10(3):182-92. doi: 10.1038/nri2724.

WASP: a key immunological multitasker.

Author information

1
Molecular Immunology Unit and Centre for Immunodeficiency, University College London Institute of Child Health, London, UK.

Abstract

The Wiskott-Aldrich syndrome protein (WASP) is an important regulator of the actin cytoskeleton that is required for many haematopoietic and immune cell functions, including effective migration, phagocytosis and immune synapse formation. Loss of WASP activity leads to Wiskott-Aldrich syndrome, an X-linked disease that is associated with defects in a broad range of cellular processes, resulting in complex immunodeficiency, autoimmunity and microthrombocytopenia. Intriguingly, gain of function mutations cause a separate disease that is mainly characterized by neutropenia. Here, we describe recent insights into the cellular mechanisms of these two related, but distinct, human diseases and discuss their wider implications for haematopoiesis, immune function and autoimmunity.

PMID:
20182458
DOI:
10.1038/nri2724
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center