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Acad Med. 2010 Mar;85(3):457-62. doi: 10.1097/ACM.0b013e3181ccb74d.

Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards.

Author information

1
Duke Translational Medicine Institute, Durham, North Carolina 27710, USA. robert.califf@duke.edu

Abstract

A comprehensive system for translating basic biomedical research into useful and effectively implemented clinical diagnostic, preventive, and therapeutic practices is essential to the nation's health. The state of clinical and translational research (CTR) in the United States, however, has been characterized as fragmented, slow, expensive, and poorly coordinated. As part of its Roadmap Initiative, the National Institutes of Health instituted the Clinical and Translational Science Awards (CTSA), a sweeping and ambitious program designed to transform the conduct of biomedical research in the United States by speeding the translation of scientific discoveries into useful therapies and then developing methods to ensure that those therapies reach the patients who need them the most. The authors review the circumstances of the U.S. biomedical research enterprise that led to the creation of the CTSA and discuss the initial strategic plan of the CTSA, which was developed from the first three years of experience with the program and was designed to overcome organizational, methodological, and cultural barriers within and among research institutions. The authors also describe the challenges encountered during these efforts and discuss the promise of this vital national health care initiative, which is essential to creating a pipeline for the scientific workforce needed to conduct research that will, in turn, provide a rational evidence base for better health in the United States.

PMID:
20182118
PMCID:
PMC4552187
DOI:
10.1097/ACM.0b013e3181ccb74d
[Indexed for MEDLINE]
Free PMC Article
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