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Development. 2010 Mar;137(6):859-70. doi: 10.1242/dev.039487.

Maternal control of early mouse development.

Author information

1
Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. lil@ioz.ac.cn

Abstract

The hiatus between oocyte and embryonic gene transcription dictates a role for stored maternal factors in early mammalian development. Encoded by maternal-effect genes, these factors accumulate during oogenesis and enable the activation of the embryonic genome, the subsequent cleavage stages of embryogenesis and the initial establishment of embryonic cell lineages. Recent studies in mice have yielded new findings on the role of maternally provided proteins and multi-component complexes in preimplantation development. Nevertheless, significant gaps remain in our mechanistic understanding of the networks that regulate early mammalian embryogenesis, which provide an impetus and opportunities for future investigations.

PMID:
20179092
PMCID:
PMC2834456
DOI:
10.1242/dev.039487
[Indexed for MEDLINE]
Free PMC Article
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