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Microbes Infect. 2010 Jun;12(6):421-7. doi: 10.1016/j.micinf.2010.02.002. Epub 2010 Feb 21.

The hygiene hypothesis: an evolutionary perspective.

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1
Scientific Institute IRCCS E. Medea, Bioinformatics, Via don L. Monza 20, 23842 Bosisio Parini (LC), Italy. manuela.sironi@bp.lnf.it

Abstract

The hygiene hypothesis relies on the assumption that humans have adapted to a pathogen-rich environment that no longer exists in industrialized societies. Recent advances in molecular immunology and population genetics allow deeper insight into the evolution and co-evolution of host-pathogen interactions and, therefore, into the foundations of the hygiene hypothesis.

PMID:
20178858
DOI:
10.1016/j.micinf.2010.02.002
[Indexed for MEDLINE]
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