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J Exp Clin Cancer Res. 2010 Feb 23;29:14. doi: 10.1186/1756-9966-29-14.

Relevance of Bcl-x expression in different types of endometrial tissues.

Author information

1
Department of Obstetrics & Gynecology, Shengjing Hospital of China Medical University, Shenyang (110004), China. maxiaoxin666@yahoo.com.cn

Abstract

OBJECTIVES:

To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs.

METHODS:

RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types.

RESULTS:

The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both P > 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (P = 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, P = 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (P = 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both P = 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (P < 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (r = -0.76).

CONCLUSION:

The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma.

PMID:
20178603
PMCID:
PMC2838817
DOI:
10.1186/1756-9966-29-14
[Indexed for MEDLINE]
Free PMC Article

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