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J Recept Signal Transduct Res. 2010 Dec;30(6):376-84. doi: 10.3109/10799891003641074. Epub 2010 Feb 24.

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.

Author information

1
Biozentrum, Division of Pharmacology/Neurobiology, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. christoph.handschin@unibas.ch

Abstract

Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways. Even though most of these pathways are activated by different stimuli and in a temporally and spatially separated manner during exercise, many of the major signal transduction events converge on the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) by post-translationally modifying the PGC-1α protein, modulating PGC-1α gene expression or both. In turn, depending on the cellular context, PGC-1α regulates specific gene programs. Ultimately, PGC-1α modulates most of the transcriptional adaptations of skeletal muscle to exercise. In this review, the regulation and function of this pivotal transcriptional coactivator in muscle are discussed.

PMID:
20178454
DOI:
10.3109/10799891003641074
[Indexed for MEDLINE]

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