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J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S126-37. doi: 10.1016/j.jaci.2009.10.028.

Drug allergy.

Author information

1
University of Texas Southwestern Medical Center, Dallas, TX 75390-8859, USA. dave.khan@utsouthwestern.edu

Abstract

Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including beta-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.

PMID:
20176256
DOI:
10.1016/j.jaci.2009.10.028
[Indexed for MEDLINE]

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