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J Cancer Res Clin Oncol. 2010 Nov;136(11):1627-31. doi: 10.1007/s00432-010-0820-0. Epub 2010 Feb 20.

Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes.

Author information

1
Department of Surgery, The Second Affiliated Hospital, College of Medicine, Cancer Institute, Zhejiang University, 88# Jiefang Road, Hangzhou 310009, People's Republic of China.

Abstract

BACKGROUND:

The relationship between diabetes and pancreatic cancer has been established by more than several decades of research. However, serum levels of CEA and CA 19-9 in diabetic pancreatic cancer has not been shown.

METHODS:

Preoperative serum levels of CEA and CA 19-9 and clinicopathological characteristics were retrospectively analyzed in 79 with or 229 without diabetes in pancreatic ductal adenocarcinoma (PDA) patients.

RESULTS:

Of the 308 PDA patients enrolled, 79 (25.6%) patients had diabetes. The percentage of new-onset diabetes (i.e. <24 months in duration) was 57% (45/79) in PDA patients coupled with diabetes. Among diabetic PDA patients, mean total bilirubin and fasting blood glucose significantly increased in comparison with control groups (8.54 ± 14.88 vs. 4.16 ± 6.12; 170.22 ± 106.96 vs. 95.84 ± 15.76; P < 0.05). No significant differences were observed in mean levels of serum CA 19-9 and CEA levels between two groups. However, when the value of CEA and CA 19-9 was analyzed as a dichotomous variable, elevated CEA (≥5 ng/ml) and CA 19-9 (≥500 U/ml) levels were strongly correlated with the presence of diabetes in PDA patients.

CONCLUSION:

Elevated CEA (≥5 ng/ml) and CA19-9 (≥500 U/ml) levels have an association with diabetic pancreatic cancer. New-onset diabetes combined with higher CA 19-9 and/or CEA might be regarded as a useful tool to screen early pancreatic cancer.

PMID:
20174821
DOI:
10.1007/s00432-010-0820-0
[Indexed for MEDLINE]

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