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Opt Express. 2010 Jan 18;18(2):1278-82. doi: 10.1364/OE.18.001278.

Collecting back-reflected photons in photoacoustic microscopy.

Author information

1
Department of Electrical Engineering and Computer Science, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. zhang25@uwm.edu

Abstract

Since the photoacoustic effect relies only on the absorbed optical energy, the back-reflected photons from samples in optical-resolution photoacoustic microscopy are usually discarded. By employing a 2 x 2 single-mode fiber optical coupler in a laser-scanning optical-resolution photoacoustic microscope for delivering the illuminating laser light and collecting the back reflected photons, a fiber-optic confocal microscope is integrated with the photoacoustic microscope. Thus, simultaneous multimodal imaging can be achieved with a single light source and images from the two modalities are intrinsically registered. Such capabilities are demonstrated in imaging both phantoms and small animals in vivo.

PMID:
20173952
PMCID:
PMC2896224
DOI:
10.1364/OE.18.001278
[Indexed for MEDLINE]
Free PMC Article

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