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Opt Express. 2010 Jan 18;18(2):938-46. doi: 10.1364/OE.18.000938.

Image patterned molecular delivery into live cells using gold particle coated substrates.

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1
Department of Electrical Engineering, University of California, Los Angeles (UCLA), 420 Westwood Plaza, 48-121 Engineering IV, Los Angeles, CA 90095-1597, USA.

Abstract

An image-patterned molecular delivery system for mammalian cells is demonstrated by pulsed laser irradiation of gold particles immobilized on a substrate below a cell monolayer. Patterned cavitation bubble nucleation was captured using a time-resolved imaging system and molecular delivery verified by observing the uptake of a membrane-impermeable fluorescent dye, calcein. Delivery efficiency as high as 90% was observed and multiplexed, patterned dye delivery was demonstrated.

PMID:
20173916
PMCID:
PMC3369548
[Indexed for MEDLINE]
Free PMC Article
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