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Nat Med. 2010 Mar;16(3):319-23. doi: 10.1038/nm.2089. Epub 2010 Feb 21.

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys.

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1
Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. dbarouch@bidmc.harvard.edu

Abstract

The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development. Antigens derived from natural HIV-1 sequences have elicited only a limited breadth of cellular immune responses in nonhuman primate studies and clinical trials to date. Polyvalent 'mosaic' antigens, in contrast, are designed to optimize cellular immunologic coverage of global HIV-1 sequence diversity. Here we show that mosaic HIV-1 Gag, Pol and Env antigens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors markedly augmented both the breadth and depth without compromising the magnitude of antigen-specific T lymphocyte responses as compared with consensus or natural sequence HIV-1 antigens in rhesus monkeys. Polyvalent mosaic antigens therefore represent a promising strategy to expand cellular immunologic vaccine coverage for genetically diverse pathogens such as HIV-1.

PMID:
20173752
PMCID:
PMC2834868
DOI:
10.1038/nm.2089
[Indexed for MEDLINE]
Free PMC Article

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