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Nat Genet. 2010 Mar;42(3):200-2. doi: 10.1038/ng.535. Epub 2010 Feb 21.

Variants in FAM13A are associated with chronic obstructive pulmonary disease.

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1
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00292552.

PMID:
20173748
PMCID:
PMC2828499
DOI:
10.1038/ng.535
[Indexed for MEDLINE]
Free PMC Article
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