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Nat Neurosci. 2010 Mar;13(3):287-289. doi: 10.1038/nn.2500. Epub 2010 Feb 21.

Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.

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1
Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
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Contributed equally

Abstract

We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.

PMID:
20173746
PMCID:
PMC4681435
DOI:
10.1038/nn.2500
[Indexed for MEDLINE]
Free PMC Article
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