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Nat Cell Biol. 2010 Mar;12(3):209-11. doi: 10.1038/ncb0310-209. Epub 2010 Feb 21.

Myc-modulated miR-9 makes more metastases.

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1
Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

Abstract

The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin. This primes the cancer cells for epithelial-mesenchymal transition (EMT) and also stimulates angiogenesis in tumours.

PMID:
20173743
DOI:
10.1038/ncb0310-209
[Indexed for MEDLINE]
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