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Neurodegener Dis. 2010;7(1-3):68-75. doi: 10.1159/000285509. Epub 2010 Feb 18.

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.

Author information

1
Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA.

Abstract

Increasing evidence supports a putative link between LRRK2 function and the MAP kinase cascades. We recently demonstrated that LRRK2 binds to MKK6, -3, and -7. Previous studies demonstrated that scaffold proteins are essential in the regulation of subcellular localization of stress kinase complexes. The c-jun NH2-terminal kinase (JNK)-interacting proteins (JIPs) are a group of scaffold proteins that play an important role in the regulation of MAP kinase signaling cascades. JIP1-3 are known to regulate the specificity and localization of the JNK pathway, while JIP4 is a specific scaffolding protein for the p38 pathway. We demonstrate that LRRK2 binds to JIP1-4, and is associated with increased levels of total JIP1, -3, -4, oligomeric JIP and ubiquitinated JIP. These results are consistent with a putative role of LRRK2 in regulating the stress kinase cascade.

PMID:
20173330
PMCID:
PMC2859233
DOI:
10.1159/000285509
[Indexed for MEDLINE]
Free PMC Article

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