Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1851-3. doi: 10.1016/j.bmcl.2010.01.143. Epub 2010 Feb 2.

Identification of a urea bioisostere of a triazole oxytocin antagonist.

Author information

1
Discovery Chemistry, Pfizer Global Research and Development, Sandwich, United Kingdom. Alan.D.Brown@pfizer.com

Abstract

A series of azetidine ureas were investigated as potential bioisosteres of previously reported azetidinyltriazole oxytocin antagonists. Although potency was somewhat reduced in several close-in analogues, one compound, 9, was both a potent oxytocin antagonist and demonstrated significant selectivity over the closely related vasopressin V(1A) receptor.

PMID:
20172721
DOI:
10.1016/j.bmcl.2010.01.143
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center