Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur Urol. 2010 Aug;58(2):275-80. doi: 10.1016/j.eururo.2010.02.002. Epub 2010 Feb 13.

Age-specific risk of incident prostate cancer and risk of death from prostate cancer defined by the number of affected family members.

Author information

1
Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 580, Heidelberg, Germany. andreas.brandt@dkfz.de

Abstract

BACKGROUND:

The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations.

OBJECTIVE:

Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives.

DESIGN, SETTING, AND PARTICIPANTS:

The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial.

MEASUREMENTS:

The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers.

RESULTS AND LIMITATIONS:

The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men <65 yr of age with three affected brothers (HR: approximately 23) and the lowest for men between 65 and 74 yr of age with an affected father (HR: approximately 1.8). The HRs increased with decreasing paternal or fraternal diagnostic age. The pattern of the risk of death from familial PCa was similar to the incidence data.

CONCLUSIONS:

The present results should guide clinical counselling and demonstrate the vast increases in risk when multiple first-degree relatives are affected.

PMID:
20171779
DOI:
10.1016/j.eururo.2010.02.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center