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Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S50-7. doi: 10.1016/j.ijrobp.2009.04.096.

Radiation therapy and hearing loss.

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1
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

Abstract

A review of literature on the development of sensorineural hearing loss after high-dose radiation therapy for head-and-neck tumors and stereotactic radiosurgery or fractionated stereotactic radiotherapy for the treatment of vestibular schwannoma is presented. Because of the small volume of the cochlea a dose-volume analysis is not feasible. Instead, the current literature on the effect of the mean dose received by the cochlea and other treatment- and patient-related factors on outcome are evaluated. Based on the data, a specific threshold dose to cochlea for sensorineural hearing loss cannot be determined; therefore, dose-prescription limits are suggested. A standard for evaluating radiation therapy-associated ototoxicity as well as a detailed approach for scoring toxicity is presented.

PMID:
20171518
PMCID:
PMC3319461
DOI:
10.1016/j.ijrobp.2009.04.096
[Indexed for MEDLINE]
Free PMC Article
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