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Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S28-35. doi: 10.1016/j.ijrobp.2009.07.1753.

Radiation dose-volume effects of optic nerves and chiasm.

Author information

1
Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA. charles.mayo@umassmemorial.org

Abstract

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

PMID:
20171514
DOI:
10.1016/j.ijrobp.2009.07.1753
[Indexed for MEDLINE]

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