Format

Send to

Choose Destination
Insect Biochem Mol Biol. 2010 Mar;40(3):189-204. doi: 10.1016/j.ibmb.2010.02.001. Epub 2010 Feb 18.

Structural cuticular proteins from arthropods: annotation, nomenclature, and sequence characteristics in the genomics era.

Author information

1
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. jhwillis@cb.uga.edu

Abstract

The availability of whole genome sequences of several arthropods has provided new insights into structural cuticular proteins (CPs), in particular the distribution of different families, the recognition that these proteins may comprise almost 2% of the protein coding genes of some species, and the identification of features that should aid in the annotation of new genomes and EST libraries as they become available. Twelve CP families are described: CPR (named after the Rebers and Riddiford Consensus); CPF (named because it has a highly conserved region consisting of about forty-four amino acids); CPFL (like the CPFs in a conserved C-terminal region); the TWDL family, named after a picturesque phenotype of one mutant member; four families in addition to TWDL with a preponderance of low complexity sequence that are not member of the families listed above. These were named after particular diagnostic features as CPLCA, CPLCG, CPLCW, CPLCP. There are also CPG, a lepidopteran family with an abundance of glycines, the apidermin family, named after three proteins in Apis mellifera, and CPAP1 and CPAP3, named because they have features analogous to peritrophins, namely one or three chitin-binding domains. Also described are common motifs and features. Four unusual CPs are discussed in detail. Data that facilitated the analysis of sequence variation of single CP genes in natural populations are analyzed.

PMID:
20171281
PMCID:
PMC2872936
DOI:
10.1016/j.ibmb.2010.02.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center