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Curr Opin Immunol. 2010 Apr;22(2):251-7. doi: 10.1016/j.coi.2010.01.020. Epub 2010 Feb 17.

Adoptive T cell therapy of cancer.

Author information

1
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.

Abstract

Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.

PMID:
20171074
PMCID:
PMC3093371
DOI:
10.1016/j.coi.2010.01.020
[Indexed for MEDLINE]
Free PMC Article

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