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J Infect Dis. 2010 Apr 1;201(7):1024-30. doi: 10.1086/651199.

Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses.

Author information

1
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA. Adriana.Weinberg@ucdenver.edu

Abstract

BACKGROUND:

Varicella-zoster virus (VZV)-specific cell-mediated immunity is important for protection against VZV disease. We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals.

METHODS:

VZV responder cell frequency (RCF) determinations from 752 healthy and 200 HIV-infected subjects were used to identify group-specific regression curves on age.

RESULTS:

In healthy individuals with past varicella, VZV RCF peaked at 34 years of age. Similarly, VZV-RCF after varicella vaccine increased with age in subjects aged <1 to 43 years. In subjects aged 61-90 years, VZV RCF after zoster vaccine decreased with age. HIV-infected children had lower VZV RCF estimates than HIV-infected adults. In both groups, VZV RCF results were low and constant over age. Varicella vaccination of HIV-infected children with CD4 levels 20% generated VZV RCF values higher than wild-type infection and comparable to vaccine-induced responses of healthy children.

CONCLUSIONS:

In immunocompetent individuals with prior varicella, VZV RCF peaked in early adulthood. Administration of varicella vaccine to HIV-infected or uninfected individuals aged >5 years generated VZV RCF values similar to those of immunocompetent individuals with immunity induced by wild-type infection. A zoster vaccine increased the VZV RCF of elderly adults aged <75 years to values higher than peak values induced by wild-type infection.

PMID:
20170376
PMCID:
PMC3136368
DOI:
10.1086/651199
[Indexed for MEDLINE]
Free PMC Article
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