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Nat Rev Genet. 2010 Mar;11(3):221-33. doi: 10.1038/nrg2712.

Mammalian recombination hot spots: properties, control and evolution.

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1
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. ken.paigen@jax.org

Abstract

Recombination, together with mutation, generates the raw material of evolution, is essential for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to construct genome-scale, high-resolution recombination maps and new molecular techniques for analysing recombination products have substantially furthered our understanding of this important biological phenomenon in humans and mice: from describing the properties of recombination hot spots in male and female meiosis to the recombination landscape along chromosomes. This progress has been accompanied by the identification of trans-acting systems that regulate the location and relative activity of individual hot spots.

PMID:
20168297
PMCID:
PMC4389181
DOI:
10.1038/nrg2712
[Indexed for MEDLINE]
Free PMC Article
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