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Neuroscience. 2010 May 5;167(2):354-60. doi: 10.1016/j.neuroscience.2010.02.023. Epub 2010 Feb 16.

Depolarization induces acetylation of histone H2B in the hippocampus.

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1
National Brain Research Centre, Manesar, Haryana-122050, India.

Abstract

Phosphorylation is critically involved in synaptic plasticity and memory. Recent studies have shown that another posttranslational modification, acetylation, particularly of histone H3, also plays important roles in long-term potentiation and memory. However, activity-dependent modification of different histones of the nucleosome is not clearly understood. Here we show that depolarization enhances acetylation of histone H2B in the CA1 region of the hippocampus. Depolarization-induced H2B acetylation is dependent on calcium/calmodulin-dependent kinase and extracellular signal-regulated kinase activity. In addition, inhibition of DNA methyltransferase activity also abolishes depolarization-induced increase in H2B acetylation. These results show that acetylation of histone H2B is regulated in an activity-dependent manner by the molecular events important for synaptic plasticity and memory.

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