Format

Send to

Choose Destination
Free Radic Res. 2010 Mar;44(3):275-82. doi: 10.3109/10715760903468758.

Radioprotective effect of hydrogen in cultured cells and mice.

Author information

1
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China.

Abstract

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ionizing irradiation(IR)-induced Human Lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro. This paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo. It is suggested that hydrogen has a potential as an effective and safe radioprotective agent.

PMID:
20166892
DOI:
10.3109/10715760903468758
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center