Format

Send to

Choose Destination
See comment in PubMed Commons below
J Immunol. 2010 Mar 1;184(5):2237-42. doi: 10.4049/jimmunol.0902871.

Different bacterial pathogens, different strategies, yet the aim is the same: evasion of intestinal dendritic cell recognition.

Author information

  • 1Department of Microbiology and Immunology, University of Melbourne, Gate 11, Royal Parade, Parkville 3010, Victoria, Australia. E-mail address: sbedoui@unimelb.edu.au

Abstract

Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4(+) T cells in the bacteria's favor.

PMID:
20164434
DOI:
10.4049/jimmunol.0902871
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center